Steroids

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A steroid is an organic compound with four rings arranged in a specific molecular configuration, composed of seventeen carbon atoms, bonded in four "fused" rings: three six-member cyclohexane rings (rings A, B and C in the first illustration) and one five-member cyclopentane ring (the D ring). Hundreds of steroids are found in plants, animals and fungi. Examples include the dietary lipid cholesterol, the sex hormones estradiol and testosterone and the anti-inflammatory drug dexamethasone. Steroids have two principal biological functions: certain steroids (such as cholesterol) are important components of cell membranes which alter membrane fluidity, and many steroids are signaling molecules which activate steroid hormone receptors.

Steroids (318):

Cat. No.	Product Name	CAS No.	Purity	Chemical Structure

HY-N0583

Hydrocortisone 50-23-7 99.91%

Hydrocortisone (Cortisol) is a steroid hormone or glucocorticoid secreted by the adrenal cortex^[1].

Hydrocortisone	50-23-7	99.91%
Hydrocortisone (Cortisol) is a steroid hormone or glucocorticoid secreted by the adrenal cortex^[1].

HY-B0141

Estradiol	50-28-2	99.99%
Estradiol (β-Estradiol) is a steroid hormone and the major female sex hormone. Estradiol can up-regulate the expression of neural markers of human endometrial stem cells (hEnSCs) and promote their neural differentiation. Estradiol can be used for the research of cancers, neurodegenerative diseases and neural tissue engineering^[1]^[2].

HY-B1618

Corticosterone	50-22-6
Corticosterone (17-Deoxycortisol) is an orally active and adrenal cortex-produced glucocorticoid, which plays an important role in regulating neuronal functions of the limbic system (including hippocampus, prefrontal cortex, and amygdala). Corticosterone increases the Rab-mediated AMPAR membrane traffic via SGK-induced phosphorylation of GDI. Corticosterone also interferes with the maturation of dendritic cells and shows a good immunosuppressive effect^[1]^[2]^[3]^[4].

HY-N0322

Cholesterol	57-88-5
Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins^[1]^[2]. Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist^[3].

HY-N0437

Progesterone 57-83-0 99.79%

Progesterone is a steroid hormone that regulates the menstrual cycle and is crucial for pregnancy.

Progesterone	57-83-0	99.79%
Progesterone is a steroid hormone that regulates the menstrual cycle and is crucial for pregnancy.

HY-N0171A

Beta-Sitosterol (purity>98%)	83-46-5
Beta-Sitosterol (purity>98%) is a plant sterol. Beta-Sitosterol (purity>98%) interfere with multiple cell signaling pathways, including cell cycle, apoptosis, proliferation, survival, invasion, angiogenesis, metastasis and inflammation^[1].

HY-113134

25-Hydroxycholesterol	2140-46-7
25-Hydroxycholesterol (25-OHC) is a metabolite of cholesterol that is produced and secreted by macrophages in response to Toll-like receptor (TLR) activation. 25-hydroxycholesterol is a potent (EC₅₀≈65 nM) and selective suppressor of IgA production by B cells.

HY-17024

Cyclopamine 4449-51-8

Cyclopamine is a Hedgehog (Hh) pathway antagonist with an IC₅₀ of 46 nM in the Hh cell assay. Cyclopamine is also a selective Smo inhibitor.

Cyclopamine	4449-51-8
Cyclopamine is a Hedgehog (Hh) pathway antagonist with an IC₅₀ of 46 nM in the Hh cell assay. Cyclopamine is also a selective Smo inhibitor.

HY-12033

2-Methoxyestradiol	362-07-2	99.82%
2-Methoxyestradiol (2-ME2), an orally active endogenous metabolite of 17β-estradiol (E2), is an apoptosis inducer and an angiogenesis inhibitor with potent antineoplastic activity. 2-Methoxyestradiol also destablize microtubules. 2-Methoxyestradio, also a potent superoxide dismutase (SOD) inhibitor and a ROS-generating agent, induces autophagy in the transformed cell line HEK293 and the cancer cell lines U87 and HeLa^[1]^[2]^[3]^[4]^[5]^[6].

HY-B0469

Medroxyprogesterone acetate 71-58-9 99.88%

Medroxyprogesterone acetate is a widely used synthetic steroid by its interaction with progesterone, androgen and glucocorticoid receptors^[1].

Medroxyprogesterone acetate	71-58-9	99.88%
Medroxyprogesterone acetate is a widely used synthetic steroid by its interaction with progesterone, androgen and glucocorticoid receptors^[1].

HY-17463

Prednisolone	50-24-8	99.96%
Prednisolone is a potent, orally active corticosteroid and a glucocorticoid. Prednisolone possesses about four times the anti-inflammatory activity of hydrocortisone while causing less salt and water retention. Prednisolone can be used for ocular, anti-inflammatory research^[1]^[2].

HY-19696A

Tauroursodeoxycholate sodium	35807-85-3
Tauroursodeoxycholate (Tauroursodeoxycholic acid; TUDCA) sodium is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.

HY-N2334

Glycochenodeoxycholic acid	640-79-9
Glycochenodeoxycholic acid (Chenodeoxycholylglycine) is a bile acid formed in the liver from chenodeoxycholate and glycine. It acts as a detergent to solubilize fats for absorption and is itself absorbed. Glycochenodeoxycholic acid (Chenodeoxycholylglycine) induces hepatocyte apoptosis^[1]^[2].

HY-113313

Aldosterone	52-39-1
Aldosterone is the primary mineralocorticoid. Aldosterone is a steroid hormone, and it is synthesized and secreted in response to renin-angiotensin system activation (RAS) or high dietary potassium by the zona glomerulosa (ZG) of the adrenal cortex. Aldosterone activity is dependent by the binding and activation of the cytoplasmic/nuclear mineralocorticoid receptor (MR) at cellular level^[1]^[2].

HY-N6979

Crustecdysone	5289-74-7	99.63%
Crustecdysone (20-Hydroxyecdysone) is a naturally occurring ecdysteroid hormone isolated from Serratula coronata which controls the ecdysis (moulting) and metamorphosis of arthropods, it inhibits caspase activity and induces autophagy via the 20E nuclear receptor complex, EcR-USP^[1]. Crustecdysone exhibits regulatory or protective roles in the cardiovascular system^[2]. Crustecdysone is an active metabolite of Ecdysone (HY-N0179)^[3].

HY-N2027

Taurochenodeoxycholic acid	516-35-8
Taurochenodeoxycholic acid (12-Deoxycholyltaurine) is one of the main bioactive substances of animals' bile acid. Taurochenodeoxycholic acid induces apoptosis and shows obvious anti-inflammatory and immune regulation properties^[1]^[2].

HY-N1459

Campesterol 474-62-4

Campesterol is a plant sterol with cholesterol lowering and anticarcinogenic effects.

Campesterol	474-62-4
Campesterol is a plant sterol with cholesterol lowering and anticarcinogenic effects.

HY-N0131

Stigmasterol	83-48-7
Stigmasterol is a plant sterol which has been focused on the cholesterol-lowering activity and is valued as an anti-stiffness factor in the therapy of rheumatic diseases.

HY-B0234

Estrone	53-16-7
Estrone (E1) is a natural estrogenic hormone. Estrone is the main representative of the endogenous estrogens and is produced by several tissues, especially adipose tissue. Estrone is the result of the process of aromatization of androstenedione that occurs in fat cells^[1]^[2].

HY-N0877

Bufalin	465-21-4	99.86%
Bufalin is an active component isolated from Chan Su, acts as a potent Na⁺/K⁺-ATPase inhibitor, binds to the subunit α1, α2 and α3, with K_d of 42.5, 45 and 40 nM, respectively^[1]^[2]. Anti-cancer activity^[2].