Quinones

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The quinones represent a class of organic compounds that are formally "derived from aromatic compounds [such as benzene or naphthalene] by conversion of an even number of -CH= groups into -C(=O)- groups with any necessary rearrangement of double bonds", resulting in "a fully conjugated cyclic dione structure". The class includes some heterocyclic compounds. A large scale industrial application of quinones is for the production of hydrogen peroxide. Natural quinones show a biological or pharmacological activity, and some of them show anti-tumoral activity. They embody some claims in herbal medicine. Some quinone derivatives are used for coloring substances (dyes and pigments) and oxidizing agents.

Quinones (180):

Cat. No.	Product Name	CAS No.	Purity	Chemical Structure

HY-15142

Doxorubicin hydrochloride	25316-40-9
Doxorubicin (Hydroxydaunorubicin) hydrochloride, a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent. Doxorubicin hydrochloride is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC₅₀s of 0.8 μM and 2.67 μM, respectively. Doxorubicin hydrochloride reduces basal phosphorylation of AMPK and its downstream target acetyl-CoA carboxylase. Doxorubicin hydrochloride induces apoptosis and autophagy^[1]^[2]^[3].

HY-N0822

Shikonin	517-89-5	99.80%
Shikonin is a major component of a Chinese herbal medicine named zicao. Shikonin is a potent TMEM16A chloride channel inhibitor with an IC₅₀ of 6.5 μM^[1]. Shikonin is a specific pyruvate kinase M2 (PKM2) inhibitor^[2] and can also inhibit TNF-α and NF-κB pathway^[3]. Shikonin decreases exosome secretion through the inhibition of glycolysis^[4]. Shikonin inhibits AIM2 inflammasome activation^[7].

HY-13062

Daunorubicin hydrochloride	23541-50-6	99.62%
Daunorubicin (Daunomycin) hydrochloride is a topoisomerase II inhibitor with potent anti-tumor activity. Daunorubicin hydrochloride inhibits DNA and RNA synthesis. Daunorubicin hydrochloride is a cytotoxin that inhibits cancer cell viability and induces apoptosis and necrosis. Daunorubicin hydrochloride is also an anthracycline antibiotic. Daunorubicin hydrochloride can be used in the research of infection and variety of cancers, including leukemia, non-Hodgkin lymphomas, Ewing's sarcoma, Wilms' tumor^[1]^[2]^[4]^[5].

HY-13502

Mitoxantrone	65271-80-9
Mitoxantrone is a potent topoisomerase II inhibitor. Mitoxantrone also inhibits protein kinase C (PKC) activity with an IC₅₀ of 8.5 μM. Mitoxantrone induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone shows antitumor activity^[1]^[2]^[3]^[4]. Mitoxantrone also has anti-orthopoxvirus activity with EC₅₀s of 0.25 μM and and 0.8 μM for cowpox and monkeypox, respectively^[5].

HY-15230

Geldanamycin	30562-34-6
Geldanamycin is a Hsp90 inhibitor with antimicrobial activity against many Gram-positive and some Gram-negative bacteria. Geldanamycin has anti-influenza virus H5N1 activities.

HY-B0332

Menadione 58-27-5 99.53%

Menadione is a naphthoquinone that is converted into active vitamin K2 in the body. Menadione is a potential anticancer agent and radiosensitizer^[1].
HY-N0111

Coenzyme Q10 303-98-0

Coenzyme Q10 is an essential cofactor of the electron transport chain and a potent antioxidant agent.

Menadione	58-27-5	99.53%
Menadione is a naphthoquinone that is converted into active vitamin K2 in the body. Menadione is a potential anticancer agent and radiosensitizer^[1].

Coenzyme Q10	303-98-0
Coenzyme Q10 is an essential cofactor of the electron transport chain and a potent antioxidant agent.

HY-14393

Emodin	518-82-1	99.20%
Emodin (Frangula emodin), an anthraquinone derivative, is an anti-SARS-CoV compound. Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 (ACE2) interaction^[1]. Emodin inhibits casein kinase-2 (CK2). Anti-inflammatory and anticancer effects^[2]. Emodin is a potent selective 11β-HSD1 inhibitor with the IC₅₀ of 186 and 86 nM for human and mouse 11β-HSD1, respectively. Emodin ameliorates metabolic disorder in diet-induced obese mice^[3].

HY-N0135

Tanshinone IIA	568-72-9	99.74%
Tanshinone IIA (Tan IIA) is one of the main compositions in the root of Salvia miltiorrhiza Bunge. Tanshinone IIA may suppress angiogenesis by targeting the protein kinase domains of VEGF/VEGFR2.

HY-N0174

Cryptotanshinone	35825-57-1	98.69%
Cryptotanshinone is a natural compound extracted from the root of Salvia miltiorrhiza Bunge that shows antitumor activities. Cryptotanshinone inhibits STAT3 with an IC₅₀ of 4.6 μM.

HY-N0142

Phloretin	60-82-2	99.67%
Phloretin (NSC 407292; RJC 02792) is a flavonoid extracted from Malus pumila Mill., has anti-inflammatory activities. Phloridzin is a specific, competitive and orally active inhibitor of sodium/glucose cotransporters in the intestine (SGLT1) and kidney (SGLT2). Phloretin inhibits Yeast-made GLUT1 as well as Human erythrocyte GLUT1 with IC₅₀values of 49 μM and 61 μM, respectively^[1].Phloretin has the potential for the treatment of rheumatoid arthritis (RA) and allergic airway inflammation^[4].

HY-N0684

Vitamin K1 84-80-0

Vitamin K1 a naturally occurring vitamin required for blood coagulation and bone and vascular metabolism.

Vitamin K1	84-80-0
Vitamin K1 a naturally occurring vitamin required for blood coagulation and bone and vascular metabolism.

HY-13502A

Mitoxantrone dihydrochloride	70476-82-3	99.55%
Mitoxantrone dihydrochloride is a potent topoisomerase II inhibitor. Mitoxantrone dihydrochloride also inhibits protein kinase C (PKC) activity with an IC₅₀ of 8.5 μM. Mitoxantrone dihydrochloride induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone dihydrochloride shows antitumor activity^[1]^[2]^[3]^[4]. Mitoxantrone dihydrochloride also has anti-orthopoxvirus activity with EC₅₀s of 0.25 μM and and 0.8 μM for cowpox and monkeypox, respectively^[5].

HY-N0105

Rhein 478-43-3 98.06%

Rhein is an anthraquinone compound with anti-inflammatory, antioxidant, and anti-cancer effects^{[1]^.}

Rhein	478-43-3	98.06%
Rhein is an anthraquinone compound with anti-inflammatory, antioxidant, and anti-cancer effects^{[1]^.}

HY-13555

β-Lapachone	4707-32-8	99.99%
β-Lapachone (ARQ-501;NSC-26326) is a naturally occurring O-naphthoquinone, acts as a topoisomerase I inhibitor, and induces apoptosis by inhibiting cell cycle progression.

HY-N0283

Diacerein	13739-02-1
Diacerein (Diacerhein), an orally active anthraquinone, reduces production of IL-1 converting enzyme then inhibits the activation of IL-1β by related downstream signaling. Diacerein is an anti-inflammatory and anti-rheumatic drug. Diacerein can relieve bronchospasm and control airway inflammation in asthmatic mice. Diacerein has the potential for slow acting drug in osteoarthritis (SYSADOA) research^[1]^[2]^[3].

HY-N0108

Physcion	521-61-9
Physcion (Parietin) is an anthraquinone isolated from traditional Chinese medicine Radix et Rhizoma Rhei, acts as an inhibitor of 6-phosphogluconate dehydrogenase, with an IC₅₀ and a K_d of 38.5 μM and 26.0 μM, respectively^[1]^[2]. Physcion (Parietin) exhibits laxative, hepatoprotective, anti-inflammatory, anti-microbial, anti-proliferative and anti-tumor effects^[2].

HY-17473

Embelin	550-24-3	98.75%
Embelin (Embelic acid), a potent, nonpeptidic XIAP inhibitor (IC₅₀=4.1 μM), inhibits cell growth, induces apoptosis, and activates caspase-9 in prostate cancer cells with high levels of XIAP. Embelin blocks NF-kappaB signaling pathway leading to suppression of NF-kappaB-regulated antiapoptotic and metastatic gene products. Embelin also induces autophagic and apoptotic cell death in human oral squamous cell carcinoma cells^[1]^[2]^[3].

HY-N0189

Aloe emodin	481-72-1
Aloe emodin (Rhabarberone) is a natural hydroxyanthraquinone with antitumor activities. aloe-emodin can bind with mTORC2 and inhibit its kinase activity. Aloe emodin exerts antiproliferation effects and induces cellular apoptosis^[1]. Aloe emodin also exhibits antiviral activity that against influenza A virus^[2].

HY-101415

Coenzyme Q9	303-97-9
Coenzyme Q9 (Ubiquinone Q9), the major form of ubiquinone in rodents, is an amphipathic molecular component of the electron transport chain that functions as an endogenous antioxidant. Coenzyme Q9 attenuates the diabetes-induced decreases in antioxidant defense mechanisms. Coenzyme Q9 improves left ventricular performance and reduces myocardial infarct size and cardiomyocyte apoptosis^[1]^[2].