2. Autophagy
    PROTAC
  3. ATTECs

ATTECs

ATTECs

Related Products

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Autophagosome-tethering compound (ATTEC) degrades target proteins via lysosomal pathway rather than common proteasome pathway. ATTEC degrades target proteins by molecular glue mechanism, and its molecular weight is smaller than AUTAC. ATTEC shorten the distance between LC3 receptor and target protein and then the target protein was phagocytosed and transferred into lysosomal for degradation.

ATTECs Related Products (7):

Cat. No. Product Name Effect Purity
  • HY-157458
    PDEδ autophagic degrader 1
    PDEδ autophagic degrader 1 (compound 12c) is a potent PDEδ autophagic degrader. PDEδ autophagic degrader 1 reduces the PDEδ protein level through lysosome-mediated autophagy without affecting the PDEδ mRNA expression. PDEδ autophagic degrader 1 suppresses the growth in KRAS mutant pancreatic cancer cells[1].
  • HY-W867929
    LD-ATTEC3
    LD-ATTEC3 is a lipid droplet-binding compound that can be used in the study of lipid metabolism-related diseases[1].
  • HY-157304
    ATTECs Degrader 1
    ATTECs Degrader 1 (Compound MT1) is an ATTECs compound. ATTECs Degrader 1 can bind to both the outer mitochondrial membrane protein (TSPO) and the autophagosome protein LC3B. ATTECs Degrader 1 enhances the degradation of damaged mitochondria by autophagosomes and subsequent autophagic degradation[1].
  • HY-130259
    LC3-mHTT-IN-AN2
    LC3-mHTT-IN-AN2 (Compound AN2) is a mHTT-LC3 linker compound, which interacts with both mutant huntingtin protein (mHTT) and LC3B but not with wtHTT or irrelevant control proteins. LC3-mHTT-IN-AN2 reduces the levels of mHTT in an allele-selective manner in cultured Huntington disease (HD) mouse neurons[1].
  • HY-130258
    LC3-mHTT-IN-AN1
    LC3-mHTT-IN-AN1 (Compound AN1) is a mHTT-LC3 linker compound, which interacts with both mutant huntingtin protein (mHTT) and LC3B but not with wtHTT or irrelevant control proteins. LC3-mHTT-IN-AN1 reduces the levels of mHTT in an allele-selective manner in cultured Huntington disease (HD) mouse neurons[1].
  • HY-157208
    LD-ATTEC2
    LD-ATTEC2, an intermediate, used for lipid metabolism-related diseases study[1].
  • HY-157209
    LD-ATTEC4
    LD-ATTEC4 (compound 4A) is a coupling compound that can bind to LC3, with a Kd of 0.39 μM for LC3B. LD-ATTEC4 can connect autophagosomes with lipid droplets, inducing autophagy to clear lipid droplets[1].